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Experimental results showed that metformin effectively lowered total testosterone levels and free androgen index ( Metformin exerts its efficacy by effectively reducing blood glucose levels, mitigating IR, and facilitating improvements in abnormal glucose metabolism markers

Glutathione depletion and recovery after acute ethanol administration in the aging mouse.Biochem Pharmacol

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E-cigarette use has been linked to metabolic dysfunction, including prediabetes and impaired fasting glucose regulation, suggesting broader systemic metabolic disruption [137]

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Given the safety limitations of pharmacologic antihypertensives during pregnancy, the exploration of nutraceuticals with anti-inflammatory and antioxidant properties has attracted increasing interest (Hup et al., 2025)