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Consequently, there are problems for their use as therapies that are related to variability of strains, variability of hosts, and the need to standardize procedures

In the case of HNE, the molecular mechanism appears to be species-specific and is dependent on the dose used (Iles and Liu, 2005

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1 Introduction Methotrexate (MTX) is a dihydrofolate reductase inhibitor and chemotherapeutic agent with proven efficiency against cancers and rheumatoid arthritis (Kozminski et al., 2020)

Almikhlafi, Taibah University, Saudi Arabia Amer Ali, Cairo University, Egypt Updates Copyright 2025 ALSuhaymi, Alsugoor, Shokry, Fayed, Mohamed, Afifi, Esatbeyoglu, Korany and Elbaset