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In complex chronic conditions like Long COVID and ME/CFS, this initial acute depletion triggers a vicious, self-perpetuating cycle of cellular dysfunction

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Smaller volumes mean less discomfort, less chance of medication leaking from the injection site, and more doses per vial

GABA is, similarly to glutamate, after cerebral ischemia, released from neurons and also microglia, and either reabsorbed by neurons or uptaken by surrounding glial cells for further metabolism (Fig