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Int J Oncol 23:503508 Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Kita T, Murai N, Naito Y, Lee SH, Ito J (2004) Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides

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Under combined Gpx4 - and vitamin E-deficiency plasma EPO and ERFE levels increased to very high and highly significant levels (Figure 6P,Q), apparently mirroring the severity of erythropenia under combined Gpx4 - and vitamin E-deficiency.52 Taken together, the defect in reticulocyte maturation by loss of the Gpx4 gene causes ineffective erythropoiesis with simultaneous iron overload in the liver and iron-deficiency in the hematopoietic system and this phenotype is to a large part masked by vitamin E in the normal diet

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