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Rotational forces, particularly internal and external rotation of the tibia, further compound the stress on the ACL, making it more susceptible to injury during dynamic movements
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NMDA receptor modulation is consistent with DSIPs observed effects on cortical EEG activity, delta-wave induction, and neuroprotective properties in stroke and hypoxia models

Preclinical Evidence and Future Research Directions Much of the compelling evidence for MOTS-c comes from preclinical studies in cell cultures and animal models
