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10.1161/01.HYP.0000203309.07140.d3 106 ErnstM

In metabolomics, metabolite set enrichment analysis is used to identify the altered metabolite sets (metabolic pathways) associated with phenotypes of interest, e.g., presence of fatigue, using algorithms which is run on a general metabolite network constructed based on public databases, i.e., KEGG (Kyoto Encyclopedia of Genes and Genomes) in the present study 57,58,59

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However, some metabolites were also reported to occur in urine of untreated animals, indicating either background contamination via animal feed or endogenous sources, which may limit their suitability as biomarkers of exposure

doi: 10.1146/annurev.phyto.050908.135202 71 WangS

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