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Additionally, Scrophulariae Radix modulates key urinary, hepatic, and serum metabolites, helping to correct hyperthyroidism-related metabolic disturbances (102)

During this process ROS is produced

Haller, G

Han, R.-M., Zhang, J.-P

Inducing ferroptosis also shows a benefit in enhancing the anticancer activity of checkpoint blockade (e.g., anti-CD274/PD-L1 and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA4)) and radiotherapy

Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung