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Looking at methionine and SAM together may help distinguish inadequate substrate from inefficient conversion or excessive downstream demand

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In clinical studies, TAMs are associated with poor prognosis, while the use of anti-inflammatory agents is associated with reduced instances of certain cancers

While glucose is essential for the normal functioning of the organism, excessive amounts can induce glucotoxicity [7][8]

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Because of their invasive character, physiological validation studies were often based on one or a few individuals 47,48,49