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Neurotrophic factors and neurogenic inflammation associated with bladder afferent hyperexcitability pathways are the featured inflammatory mechanisms in IC/BPS

Sexual satisfaction in women depends on three roughly equal factors: physical arousal quality, emotional intimacy, and psychological safety

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Major factors contributing to the increased severity of SCD include chronic inflammation and oxidant stress

Redox-mediate dysregulation of signal transduction pathways leads to uncontrolled cell growth (cancer) and cell death (neurodegenerative disorders)