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Several completed trials have reported encouraging results

Nature 562 , 538544 (2018)

Indeed, the combined therapy significantly increased the production of IL-12 by APCs and granzyme B by cytotoxic cells (CD8 + T cells and NK cells) as compared to either of the drugs alone [198]
[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Rodrguez M.L., Prez S., Mena-Moll S., Desco M.C., Ortega L

Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability

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