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64 , 65 In murine MM models, inhibiting HIF1 downregulated proangiogenic genes, including vascular endothelial growth factor, and led to a reduction in the weight and volume of the tumor burden

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Cancer 103 , 21892198 (2005)

Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research