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demonstrated that macrophages can absorb extracellular lactate to promote the lactylation of high mobility group box-1 (HMGB1), which is subsequently secreted via exosomes, increasing endothelial permeability and inducing further endothelial barrier dysfunction [163]

The pathogenic mechanism of 2HG largely impairs the TP53 downstream pathway, thereby enhancing tumor progression and cellular stress response by inhibiting -KG-dependent dioxygenase activity

A targeted drug trial of Avastin (bevacizumab) with Alimta and cisplatin reported 18.8 months of survival

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