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There are still important questions concerning the role of the gut microbiome in astrocyte function in AD that have yet to be studied

Cells were treated with LL-341070 or LL-341070A (in 0.4% DMSO) in duplicates with drug concentrations ranging from 0.031 to 10000 nM in half-log dilutions

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According to the authors, these results were unexpected, especially considering that previous studies yielded positive outcomes

p=0.003) Discussion Since the first report of the neurotoxicity of the copper chelator cuprizone in Swiss albino mice by Carlton in 1966 (Carlton, 1966) and the subsequent early description of CPZ-induced OL death and demyelination in the superior cerebellar peduncles of ICI mice (Blakemore, 1972), the CPZ-induced demyelination model has been intensively studied and optimized for more than five decades (Vega-Riquer et al., 2019)

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