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Additionally, research by Yu et al (138) suggests that TSA alleviates cerebral ischemia-reperfusion injury by downregulating TGM2, inhibiting PANX1 expression and suppressing microglial activation and neuroinflammation (TNF-, IL-1 and IL-6), highlighting the multi-target regulation of TSA in the same disease

It acts as a hormone, a local regulator, and a neurotransmitter

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Menghoum N, Oriot P, Hermans MP

We also summarize the progress in understanding the role of genetic alleles and age-related gene expression as it pertains to the phenotypic variability between patients