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Silence or correct mutations: e.g., SNCA and LRRK2 via RNA interference (RNAi) or CRISPR-Cas9 ( AAV2-based vectors have been used in clinical trials to deliver therapeutic genes to the striatum or SNpc, showing safety and moderate benefit ( 5.5 Stem cell-based approaches Stem cell therapies offer the potential to replace lost dopaminergic neurons and restore neural circuitry

However, with age, our synthesizing ability begins to decline and become short of supply

These findings demonstrate that alterations in GSTM1 KD astrocyte responses to acute brain inflammation negatively impact neuronal activities and increase their cellular stress in a non-cell autonomous manner in vivo

doi: 10.1016/j.metabol.2021.154708