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failed to show an improvement in semen parameters, sperm survival, or pregnancy rates after the administration of high-doses of Vitamin C and E for 56 days.[40] Despite that, more recent studies have conveyed a beneficial effect for antioxidant regimens-containing Vitamin C in different clinical scenarios

Busch M, Franke S, Ruster C, and Wolf G

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doi: 10.1016/S0140-6736(22)01485-4 2 GormanEAOKaneCMMcAuleyDF

Figure 6: Kaplan-Meier Curves for Overall Survival in Non-squamous NSCLC in Study JMEN Figure 7: Kaplan-Meier Curves for Overall Survival in Squamous NSCLC in Study JMEN Maintenance Treatment Following First-line Pemetrexed Plus Platinum Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was also evaluated in PARAMOUNT (NCT00789373), a multi-center, randomized (2:1), double-blind, placebo-controlled study conducted in patients with Stage IIIb/IV non-squamous NSCLC who had completed four cycles of pemetrexed in combination with cisplatin and achieved a complete response (CR) or partial response (PR) or stable disease (SD)