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Furthermore, MPTP-treated mice exhibited significantly upregulated expression levels of iNOS, TNF, and IL-1 compared to controls, whereas irisin treatment notably attenuated the expression of these pro-inflammatory markers (Fig
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doi: 10.1111/jnc.13037

Up to sevenfold increases were observed at day three

The brain is largely formed by PUFAs with high sensitivity to lipid peroxidation (Nunomura et al., 2006), motor neurons are highly sensitive to OS (Simpkins and Dykens, 2008) and the CNS has a poor antioxidant capacity with low activity of protective enzymes such as glutathione peroxidase (GPx), catalase (CAT) or superoxide dismutase (SOD) and poor capacity for cell regeneration (Fischer and Maier, 2015

Conclusion and future perspective Amino acids metabolism affects multiple levels of cell metabolism and many cell processes, from protein synthesis to epigenetic regulation