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Each pen delivers exactly one weekly dose

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Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use tirzepatide

Clinical trial participants reported the most discomfort when they first started taking tirzepatide, or when they increased their dose

Out of the total participants, 142 individuals experienced at least one MACE-4 event, with 109 from the high cardiovascular risk trial and 33 from the six trials with lower cardiovascular risk

The rationale is that smaller, more frequent doses may produce smoother drug levels with fewer peak-related side effects