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37:71-82 e12 [PubMed: 25529979] 248

The Phase 3 TRIUMPH-4 trial, which ran for 68 weeks, confirmed this the 12mg group reached 28.7% weight loss at 68 weeks versus 24.2% at 48 weeks in Phase 2

Allosteric targeting as a platform strategy for active drug delivery Research on mRNA delivery has received extensive attention, including the delivery of mRNA to specific tissues (e.g., liver, spleen, and lung) by selective organ targeting, but additional research is needed to overcome the BBB 30

The injection is given once weekly under the skin in areas such as the abdomen, thigh, or upper arm

XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic

Unfortunately, due to the increased consumption of unhealthy diets (e.g., the Western diet) and a shift towards more sedentary lifestyles, the International Diabetes Federation (IDF) Diabetes Atlas (2021) reports that more than 10% of the worlds adult population suffer from T2D, with almost half unaware of the condition