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Dive into the therapeutic potential of the Glucagon Receptor (GCGR) a class-B GPCR crucial for regulating hepatic glucose production and energy metabolism

Glucagon-like peptide-1 (GLP-1) receptor agonists are becoming widely used as treatments for type 2 diabetes, providing substantial benefits in both blood glucose control and weight loss

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Methods Adults (18 years old) with T2D required at least one prescription for injectable semaglutide at index date (treatment switch), at least one prescription for any other GLP-1 RA in the previous 365 days, a baseline HbA1c and/or weight measurement in the 90 days pre-index and a follow-up measurement at 180 and 365 days post-index

Understanding the mechanisms, risk factors, and safety considerations helps patients distinguish normal adaptation from concerning symptoms