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A recent British Medical Journal editorial said: Weight cycling is physically and psychologically burdensome for many people and can worsen health outcomes. It suggests that the chronic and relapsing nature of obesity highlights the need for some form of lifetime care

doi: 10.1161/CIRCULATIONAHA.124.067676

Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation

This can include activities like walking, swimming, or cycling

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