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doi: 10.1016/j.bbalip.2018.10.008

Metformin reduces appetite Metformin plays a role in increasing certain hormones and molecules in the body that help control hunger and fullness

Hypoglycemia: When used with insulin or insulin secretagogues (e.g., sulfonylureas), hypoglycemia may occur

Complementary Therapies in Medicine

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Deganutti G., Liang Y.L., Zhang X., Khoshouei M., Clydesdale L., Belousoff M.J., Venugopal H., Truong T.T., Glukhova A., Keller A.N., et al

High-risk populations Patients with chronic pain, rheumatoid arthritis, osteoarthritis, and other musculoskeletal disorders are considered to be at an increased risk of the adverse effects of ibuprofen usage, particularly the renal toxicity associated with this drug