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For that reason, the pill must be taken: On a completely empty stomach First thing in the morning At least 30 minutes before eating, drinking anything but water, or taking other medications This schedule can create a practical conflict for patients already taking medications that require an empty stomachsuch as levothyroxine (for thyroid conditions) or omeprazole (for acid reflux)

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Its important that people are given advice on improving their diet and exercise, rather than relying solely on the drugs, as this may help them maintain good habits when they stop taking them. Dr Marie Spreckley, researcher in prevention of diabetes and related metabolic disorders in high-risk groups at the MRC Epidemiology Unit at the University of Cambridge, said it was important to distinguish between observed data and projections and longer-term follow-up studies are now needed to confirm whether this plateau occurs in routine practice