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These genomic changes are responsible for most of the effects of thyroid hormones on target tissues

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Grawert wasnt involved in the study

At 5 mg: the first real test The jump from 2.5 to 5 mg is a doubling of dose

pharmacodynamic antagonism is clinically relevant when high-dose zinc is combined with intravenous iron dextran or oral copper supplements, potentially producing reciprocal deficiencies

therefore, prescribers usually restrict use to adults unless compelling justification exists
