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Anti-inflammatory and anti-fibrotic mechanisms Although retatrutide treatment resulted in pronounced weight loss, prior studies have shown that obesity-associated immune, metabolic, and fibrotic signatures in epididymal adipose tissue can persist despite substantial weight loss, indicating that adipose tissue remodeling cannot be fully explained by weight loss [38, 39]

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10.1212/WNL.0000000000005771 22 DefronzoR