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Supporting a role of the kidneys in GIP clearance, circulating levels of total GIP are lower in the renal relative to the hepatic and femoral vein [243], and are elevated in people living with impaired renal function [143,[244], [245], [246], [247]] and in nephrectomized rats after intraduodenal infusion of glucose [243]

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However, its important to note that while Ozempic and similar GLP-1 agonists offer benefits like blood sugar management and weight loss, they might also increase the risk of severe stomach problems

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