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This mechanism contributes to improved glycaemic control and weight reduction, as demonstrated in clinical trials

The key enzyme involved in this is sulfotransferase SULT1A1, which is highly expressed in the outer root sheath (ORS) of hair follicles

Expanding Adoption in Obesity Management Programs: Clinical adoption of semaglutide for weight management has increased significantly, with over 35% of new prescriptions in 2025 linked to obesity treatment rather than diabetes

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References 1 lvarez-SnchezN.Cruz-ChamorroI.Lpez-GonzlezA.UtrillaJ