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Patch dosing will be measured differently (typically in milligrams per day released through the skin) and will require entirely new comparison frameworks
This makes the pill easier to travel with and more convenient to store than the injectable version
Under these nonpathological conditions, coupling of glucose metabolism to K ATP channel closure is not disturbed, so that glucose is fully capable of generating the cytosolic Ca 2+ signal that stimulates insulin exocytosis
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Further, GLP-1RAs significantly reduce the risk of MI and stroke, but have a neutral effect on hospitalization for heart failure upon 5 available CVOTs [49]
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