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Shikora SA, Wolfe BM, Apovian CM, Anvari M, Sarwer DB, Gibbons RD, Ikramuddin S, Miller CJ, Knudson MB, Tweden KS, Sarr MG, Billington CJ

Pulmonary embolism occurred in 207 of 117, 577 patients (0.18%) in the tirzepatide cohort and 960 of 117, 449 patients (0.82%) in the lifestyle cohort, corresponding to an RR of 0.215 (95% CI, 0.1850.250) and an OR of 0.214 (95% CI, 0.1840.249)

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It is commonly included in studies focused on obesity, insulin resistance, and metabolic optimization

Triple agonists that are being developed to target three Gs (GLP-1, GIP, and glucagon) may also help increase metabolism

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