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To improve uptake: If youre traveling or have an irregular schedule, plan ahead

The medication works

The Discontinuation Hierarchy# Discontinuation rates due to adverse events provide a practical measure of tolerability that matters most to patients: Best tolerated: Ecnoglutide (~2%), Bioglutide (NR but minimal) Well tolerated: Semaglutide (4.3%), CT-388 (5.9%), Tirzepatide (4.3-7.1%) Moderate: Orforglipron (5.3-10.3%) Higher burden: Retatrutide (12.2-18.2%) Titration Matters# GI side effects are strongly concentrated during dose escalation

doi: 10.1038/nature22800

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Devries S., Agatston A., Aggarwal M., Aspry K.E., Esselstyn C.B., Kris-Etherton P., Miller M., O'Keefe J.H., Ros E., Rzeszut A.K., et al

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