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it can centrally inhibit bone formation by binding to leptin receptors in the hypothalamus or locally promote bone formation and inhibit bone resorption by binding to receptors expressed on the surface of osteoblasts [100]

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Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents

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doi: 10.1016/j.addbeh.2018.08.027

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The only difference is the approved use printed on the label

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