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Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin

[2] Treatment Options at Ivy Rx Weekly GLP-1 or GIP/GLP-1 injections: compounded semaglutide

described the risk of development of diabetes in patients treated with a dose equivalent to 5 mg of prednisone only for treatment lasting up to 6 months [56]

When to seek care Any new, unexplained leg swelling or pain while on semaglutide warrants a same-day medical evaluation

Clinical implication: Beyond glycemic control and weight loss, GLP-1 may directly influence reproductive function and fertility

Critical Appraisal of CVOTs and Evidence Gaps While the collective evidence from the CVOTs outlined in Table 1 is compelling, a critical appraisal reveals important heterogeneity and outstanding questions that are crucial for clinical interpretation [62]