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For a 5mg vial with 2.0 mL water: 5 / 2.0 = 2.5 mg/mL

Portion control becomes increasingly important as gastric emptying normalizes and meal-induced satiety diminishes

Tirzepatide is a 39-amino acid dual agonist targeting GLP-1R and GIPR

This hegemony is about to be permanently disrupted by a new mass market, chronic disease area, which unusually is seeing very high levels of out of pocket spend- in February 2024, Novo Nordisks CEO noted that in Europe, 80% of Wegovy sales so far were paid for out of pocket by patients- showing, against preconception, that European patients were as willing as Americans to pay for their own obesity medications 5

For muscle preservation during weight loss: Include protein regularly across the day instead of trying to fit it all into dinner

J Clin Investig 116(2):299302 Schroeder EB (2022) Management of type 2 diabetes: selecting amongst available Pharmacological agents