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As the molecular structure changes, the drug's ability to bind effectively to GLP-1 receptors may diminish, potentially reducing its glucose-lowering and appetite-suppressing effects

increase by ~100150 mcg every 2 weeks as tolerated

Taking Vyvanse within 14 days of taking an MAOI is contraindicated

The side effects are typically temporary and will fade after a few weeks

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7.4.2 Vascular cognitive impairment Given the strong indication of reduced risk of vascular dementia, dedicated trials are necessary to evaluate semaglutide in patients with established vascular cognitive impairment or those at high risk