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How GLP-1 Medications Are Processed in the Body GLP-1 receptor agonists undergo hepatic metabolism and renal clearance

Patients who do not respond to GLP-1 therapy are becoming a growing concern in diabetes care, especially as GLP-1 receptor agonists continue to gain popularity for glycemic control and weight management

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Lin DS, Lee JK, Chen WJ

[DOI] [PubMed] [Google Scholar] 57.Gerstein H.C., Colhoun H.M., Dagenais G.R., Diaz R., Lakshmanan M., Pais P., Probstfield J., Riesmeyer J.S., Riddle M.C., Rydn L., et al

This is because prescription medications like Ozempic need medical supervision to reduce the risk of abuse, habit forming, and harmful side effects

A person doing well on 1.7 mg semaglutide might transition to 7.5 mg tirzepatide and feel under-dosed, or they might find 10 mg too strong