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2024;179:p

Ethics statement The animal studies were approved by the 1

A 52-week treatment with tirzepatide (5mg, 10mg, or 15 mg) led to a significant MASH resolution without worsening liver fibrosis compared to placebo (Fig.3)

26 Experiments in pancreatic islets reveal that -arrestin limits the insulin response to GLP-1, but not GIP or tirzepatide, suggesting that the biased agonism and imbalance of tirzepatide toward the GIP receptor and its unique GLP-1 receptor signaling properties might be at the basis of its potent action
[DOI] [PMC free article] [PubMed] [Google Scholar] 222.P S, et al

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