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Description
JAMA 2021;325:14031413 [DOI] [PMC free article] [PubMed] [Google Scholar] 20
provide important new information that further illuminates pathways and strategies to optimize the use of new GLP-1R agonists for the treatment of human subjects with diabetes and/or obesity
A new Biological Psychiatry review sharpens the case that GLP-1 drugs may affect addiction through brain reward circuits, not simply by reducing appetite
Program PIONEER En el programa PIONEER de ensayos clnicos, que incluy a 9.543 adultos con diabetes tipo 2, las personas tratadas con semaglutida oral tuvieron una reduccin significativamente mayor del azcar en la sangre y una prdida de peso clnicamente relevante en comparacin con sitagliptina, empagliflozina y liraglutida
GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake
This allows multiple needle punctures of the same vial over a 28-day period essential for multi-dose peptide reconstitution in laboratory settings
