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Among the individual GLP-1RAs assessed, the largest reductions in CV risk, HbA1c, and weight outcomes were observed with combination therapy with SGLT2i and once weekly semaglutide for T2D
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GLP-1s are proving their value well beyond the scale, with benefits ranging from improved glycemic control and reduced cardiovascular risk to better mobility and quality of life
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GLP-1 stimulation induced serine phosphorylation of wild-type GLP-1R, which was abolished in all individual doublet as well as triple doublet phospho-null mutants
