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Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]

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However, the ominous octet as described by DeFronzo, suggests that multiple drugs targeting different metabolic abnormalities in type 2 diabetes are required to reduce subsequent morbidity and mortality [7]
