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So its also worth keeping an eye on whether such drugs will be more likely to cause anhedonia, they added.
Consistent with these findings, it has been demonstrated that the GLP-1R agonist Ex-4 (Ronnekleiv et al., 2014) excites ARC POMC neurons in mice
Results were presented at the 2025 EASD meeting and published in The New England Journal of Medicine

Learn more: read our full guide to microdosing tirzepatide and the GLP-1 microdosing chart

The medical rationale is straightforward: your appetite dysregulation didn't develop overnight, and it won't resolve in 12 weeks