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Tirzepatide, in contrast, is already FDA-approved and available as Mounjaro (for type 2 diabetes) and Zepbound (for obesity)

Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and in those with hypersensitivity to tirzepatide

While cardiovascular outcome data for retatrutide is still accumulating, the prudent approach for anyone with active cardiovascular disease is to remain on compounds with established cardiovascular safety profiles

Today, though, pharmaceutical companies push them as weight loss drugs

Because tirzepatide reduces visceral fat and improves insulin resistance, it has powerful cardiometabolic benefits