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GLP-1R is expressed on cocaine- and amphetamine-regulated transcript (CART)/proopiomelanocortin (POMC) neurons in the hypothalamus, which regulate satiety and termination of meals [40]
Research is mixed, but a 2025 systematic review reported that microbiome interventions (e.g., probiotics) generally improved body weight, body fat percentage, and metabolic parameters (e.g., lipid levels, glucose metabolism) in people with obesity

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