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Relation to Neuroprotection: Such synthetic substances bind to GLP-1 receptors in the cortex, hippocampus, amygdala, and basal ganglia, triggering the following signal transduction: Switching off inflammatory NF-B downstream pathways like cytokines (IL-1/IL-6) and tumor necrosis factor (TNF-)

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Many individuals benefit from: Starting slowly and increasing activity gradually is often easier to maintain long term

Phase 3 MASH trials (LIVERAGE) are ongoing

GLP-1 is a peptide hormone generated from proglucagon that is secreted after meals by enteroendocrine L-cells in the distal jejunum, ileum, and colon