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The dosing protocol can be adjusted based on individual response and tolerance

Abdominal Pain and Discomfort Between 20% and 30% of people report abdominal discomfort, ranging from mild bloating and fullness to cramping or sharp pains

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This is typically very mild and subsides within 30 to 45 minutes

While neither tirzepatide nor niacinamide requires routine dose adjustment for hepatic impairment, patients with severe liver disease should be monitored closely if treatment is deemed necessary by the prescribing provider
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