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Description
Tirzepatides dual receptor agonism may result in more weight loss and better glucose control than Ozempic which only activates the GLP-1 receptor
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It functions similarly to semaglutide by stimulating insulin release and decreasing appetite

Same incretin pathway Little added efficacy More cost More polypharmacy Rule in practice: stop DPP-4 inhibitor before starting semaglutide unless there is a very unusual reason not to

Tirzepatide more commonly causes loose stools or diarrhea, with nausea being much less common
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Since many GLP-1 users focus their limited caloric intake on protein and fiber, vitamin A-rich foods often get pushed off the plate

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