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Henceforth, researchers devised numerous strategies for drug development, mainly by evading the enzymatic degradation of bioactive GLP-1 peptide by DPP-4

doi: 10.1152/physrev.00025.2016

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Finally, similar to GLP-1 RAs, the medication should not be used in patients with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [31, 43]
