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The company has not publicly confirmed a submission date, but its quarterly investor calls have consistently described retatrutide as a "late-stage pipeline priority." Lilly could also pursue a pre-NDA meeting with the FDA, where the agency provides informal guidance on what the application should contain
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Early research involving 20 mg and 40 mg doses of retatrutide has shown occasional dose-dependent increases in pulse rate during initial treatment, which generally stabilise as the body adapts over time

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