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Description
Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

The STEP trial data shows that the cumulative incidence of gastrointestinal adverse events peaks around week 20 and plateaus thereafter
doi: 10.1002/mds.25945 81 KouliATorsneyKMKuanW-L

Neurodegeneration models require integrated brain-body systems that no current NAM replicates
This can then be continued when semaglutide is stopped to help prevent weight gain

Massive benefit just on patient convenience there with the half-life being so much longer