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IL-33 appears to have important roles in resolution of inflammation and tissue repair, but is also associated with both pro-inflammatory and anti-inflammatory functions in colitis mouse models

HDL cholesterol modestly increased across the dose range, while LDL cholesterol showed minimal change a pattern consistent with weight-mediated lipid improvements rather than direct drug effects on LDL pathways

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Malts S, et al

What were the body weight reduction results of the ACHIEVE-1 trial