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*Correspondence: Ana Karina Zambrano, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Nausea is the most common reason people stop treatment early, and its largely dose-dependent

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That suggests GLP-1s might help symptoms surrounding lipedema, such as: Improved mobility Less systemic inflammation Reduced stress on joints Better blood sugar and insulin regulation However GLP-1 has not been shown to remove lipedema fat Women may see weight loss everywhere except their legs, which can ironically make lipedema more obvious